Chigadzirwa: 2-phenylacetamide
Molecular formula: C8H9NO
Molecular uremu: 135.17
Zita reChirungu: Phenylacetamide
Hunhu: White flake kana makristasi akaita shizha.Mp 157-158 ℃, bp 280-290 ℃ (kuora).Inonyungudika mumvura inopisa uye ethanol, inonyungudika zvishoma mumvura inotonhora, ether, uye benzene.
Kushandiswa: Pakati pemishonga yakadai sepenicillin uye phenobarbital.Inoshandiswawo kugadzira phenylacetic acid, zvinonhuwira, uye mishonga yezvipembenene.
Nzira 1) Masuko F，Katsura T.US 4536599A1.1985.
Wedzera 117.2 g (1.0 mol) ye phenylacetonitrile (2), 56.1 g ye 25% potassium hydroxide solution, 291.5 g ye 35% yehydrogen peroxide aqueous solution, 1.78 g ye benzyltriethylammonium chloride, uye 351.5 g yeflakisi ye isopropano.Kurudzira uye ita pa50 ℃ kwe4 maawa.Mushure mekuita kwapera, isopropanol inoputika pasi pekumanikidzwa kwakaderedzwa, kutonhora, kusefa, kugezwa nemvura, uye kuomeswa kuwana komputa (1) 128.5 g, mp 155 ℃, ine goho re95%.
Nzira 2) Furniss BS, Hannaford AJ, Rogers V, nevamwe.Vogel's Textbook yePractical Chemistry.Longman London neNew York.Chinyorwa chechina,1978:518.
Wedzera 100 g (0.85 mol) ye phenylacetonitrile (2) uye 400 mL ye concentrated hydrochloric acid kune reaction flask.Uchikuchidzira, ita pa40 ℃ kweanenge maminetsi makumi mana, uye simudza tembiricha kusvika ku50 ℃.Ramba uchiita maminitsi makumi matatu.Kutonhorera kusvika 15 ℃ uye wobva wawedzera 400 mL yemvura inotonhora yakasvibiswa inodonha.Kutonhodza mumvura yechando yekugezera, kusefa makristasi.Wedzera yakasimba kusvika ku50 mL yemvura uye simbisa zvakakwana kubvisa phenylacetic acid.Sefa uye woomesa pa50-80 ℃ kuti uwane 95 g ye phenylacetamide (1), mp 154-155 ℃, ine goho re82%.Recrystallization ne ethanol, mp 156 ℃.
Nguva yekutumira: Kubvumbi-11-2023