Basa rinonyatsozivikanwa re melatonin nderekuvandudza kunaka kwekurara (dosage 0.1 ~ 0.3mg), kupfupisa nguva yekumuka uye nguva yekurara usati warara, kunatsiridza kunaka kwekurara, kuderedza zvakanyanya kuwanda kwekumuka panguva yekurara, kupfupisa nhanho yekurara, kureba. danho rekurara kwakadzika, uye kuderedza chikumbaridzo chekumuka mangwanani anotevera.Iine nguva yakasimba yekusiyanisa kugadzirisa basa.
Hunhu hukuru hwe melatonin ndeyekuti ndiyo yakasimba endogenous free radical scavenger inowanikwa kusvika pari zvino.Basa rekutanga re melatonin kutora chikamu mune iyo antioxidant system uye kudzivirira maseru kubva mukukuvadzwa kweiyo oxidative.Panyaya iyi, kushanda kwayo kunopfuura zvinhu zvose zvinozivikanwa mumuviri.Tsvagiridzo ichangoburwa yakaratidza kuti MT ndiye mutungamiriri-mukuru we endocrine, anodzora zviitiko zveakasiyana endocrine glands mumuviri.Iine mabasa anotevera:
Kudzivirira kuchinja kwepathological
Nokuti MT iri nyore kupinda mumasero, inogona kushandiswa kuchengetedza DNA yenyukireya.Kana DNA ikakanganiswa, inogona kutungamirira kugomarara.
Kana paine Mel yakakwana muropa, hazvisi nyore kubata cancer.
Gadzirisa circadian rhythm
Iyo secretion ye melatonin ine circadian rhythm.Mushure mehusiku, kukurudzirwa kwechiedza kunopera simba, basa re enzyme re melatonin synthesis mupineal gland rinowedzera, uye chiyero chekuvanzika che melatonin mumuviri chinowedzera zvakafanana, kusvika panhongonya na2-3 am chiyero che melatonin husiku chinokanganisa kunaka kwemhando. zvekurara.Nekukura kwezera, iyo pineal gland inodzikira kusvika calcification, zvichikonzera kupera simba kana kunyangarika kweiyo rhythm yebiological wachi, Kunyanya mushure memakore makumi matatu neshanu, mwero we melatonin yakavanzwa nemuviri wakadzikira zvakanyanya, neavhareji kuderera kwegumi. -15% makore ose e10, zvichiita kuti pave nekusagadzikana kwekurara uye mutsara wehutano hwehutano.Kudzikira kweyero yemelatonin uye kurara ndicho chimwe chezviratidzo zvakakosha zvekuchembera kwehuropi hwemunhu.Naizvozvo, kuwedzera kwe melatonin in vitro kunogona kuchengetedza mwero we melatonin mumuviri mudiki, kugadzirisa uye kudzoreredza iyo circadian rhythm, iyo isingagone kudzika kurara chete, asiwo kuvandudza hupenyu hwehupenyu, Kuvandudza kunaka kwekurara, zvinonyanya kukosha kuvandudza kushanda kwemuviri wose, kuvandudza mararamiro ehupenyu uye kunonoka kukwegura.
Melatonin imhando yehomoni inogona kukonzera kurara kwepanyama.Inogona kukunda dambudziko rekurara uye kugadzirisa kunaka kwekurara nekugadzirisa kurara kwepanyama.Musiyano mukuru uripo pakati pemelatonin nemamwe mapiritsi ekukotsira ndewekuti melatonin haina kupindwa muropa uye haina mhedzisiro iri pachena.Kutora mapiritsi e1-2 (anenge 1.5-3mg melatonin) usati warara usiku hunogona kukonzera kukotsira mukati memaminitsi makumi maviri kusvika makumi matatu, asi melatonin inozorasikirwa nekushanda mushure mambakwedza mangwanani, Mushure mekumuka, hapazove nekunzwa kwekunzwa. kuneta, kurara uye kusagona kumuka.
Kunonoka kukwegura
Iyo pineal gland yevakwegura inoderera zvishoma nezvishoma uye secretion yeMel inoderera.Kushaikwa kweMel inodiwa nenhengo dzakasiyana-siyana mumuviri zvinotungamira mukukwegura uye zvirwere.Masayendisiti anodana gland repineal kuti "wachi inochembera" yemuviri.Isu tinowedzera Mel kubva mumuviri, uyezve tinokwanisa kudzosera kumashure wachi yekukwegura.Muchirimo cha1985, masayendisiti akashandisa 19 mwedzi mbeva (makore 65 muvanhu).Mamiriro ehupenyu uye chikafu cheboka A neboka B zvakanyatsofanana, kunze kwekuti Mel akawedzerwa kumvura yekunwa yeboka A usiku, uye hapana chinhu chakawedzerwa kumvura yekunwa yeboka B. Pakutanga, pakanga pasina. musiyano pakati pemapoka maviri aya.Zvishoma nezvishoma, pakava nemusiyano unoshamisa.Mbeva dziri muboka B dzaichembera zviri pachena: mhasuru dzakanyangarika, mhanza dzakavhara ganda, dyspepsia uye cataract mumaziso.Pamwe chete, mbeva dzeboka iri dzakanga dzachembera uye dzichifa.Zvinoshamisa kuti boka A mbeva dzinonwa mvura yeMel manheru ega ega dzinotamba nevazukuru vavo.Muviri wese une bvudzi gobvu gobvu, kupenya, kugayiwa kwakanaka, uye hakuna katara mumaziso.Kana ari avhareji yenguva yeupenyu, mbeva dziri muboka B dzose dzakatambura mwedzi inopfuura 24 (yakaenzana nemakore 75 muvanhu);Avhareji yehupenyu hwemakonzo muboka A mwedzi makumi matatu (makore zana ehupenyu hwevanhu).
Regulatory effect pane central nervous system
Huwandu hukuru hwezvidzidzo zvekiriniki uye zvekuyedza zvakaratidza kuti melatonin, senge endogenous neuroendocrine hormone, ine yakananga uye isina kunanga physiological regulation pane yepakati tsinga sisitimu, ine kurapa mhedzisiro yekusagadzikana kwekurara, kushushikana uye chirwere chepfungwa, uye ine inodzivirira pamasero etsinga. .Semuenzaniso, melatonin ine sedative effect, inogonawo kurapa kuora mwoyo uye psychosis, inogona kudzivirira tsinga, inogona kubvisa marwadzo, kugadzirisa kusunungurwa kwehomoni kubva ku hypothalamus, nezvimwewo.
Kudzora maitiro ezvirwere zvemuviri
Neuroendocrine uye immune system yakabatana.Immune system uye zvigadzirwa zvayo zvinogona kuchinja basa reuroendocrine.Neuroendocrine zviratidzo zvinokanganisawo immune function.Mumakore gumi achangopfuura, kudzorwa kwe melatonin pa immune system kwakakwezva kutarisisa kwakapararira.Zvidzidzo zvekumba nekune dzimwe nyika zvinoratidza kuti hazvisi kungokanganisa kukura uye kukura kwenhengo dzemuviri, asi zvakare inodzora humoral uye cellular immune, pamwe nema cytokines.Semuenzaniso, melatonin inogona kudzora masero uye humoral immune, pamwe nemabasa emhando dzakasiyana dzemacytokines.
Regulation of cardiovascular system
Mel imhando yechiratidzo chechiedza chine mabasa mazhinji.Kuburikidza nekushandurwa kwekuvanzika kwayo, inogona kuendesa ruzivo rwekutenderera kwechiedza chezvakatipoteredza kune akakodzera tishu mumuviri, kuitira kuti mabasa avo anoshanda anogona kuenderana nekuchinja kwekunze.Naizvozvo, mwero we serum melatonin secretion unogona kuratidza inoenderana nguva yezuva uye inoenderana mwaka wegore.Iyo circadian uye mwaka rhythms yezvipenyu yakanyatsoenderana nekushanduka kwenguva nenguva kwesimba uye oxygen kupihwa kwemoyo vascular system uye yekufema system.Basa revascular system rine rhythm yakajeka ye circadian uye seasonal rhythm, kusanganisira BP, kurova kwemwoyo, kubuda kwemwoyo, renin angiotensin aldosterone, nezvimwewo. Zvidzidzo zveEpidemiological zvakawana kuti chiitiko chemyocardial infarction uye ischemic heart disease yakawedzera pamusoro mangwanani, zvichiratidza kuti kutanga-kunoenderana nenguva.Mukuwedzera, BP uye catecholamine yakaderera usiku.Mel inonyanya kuvharirwa usiku, inokanganisa akasiyana eendocrine uye biological mabasa.Ukama huri pakati peMel uye circulatory system hunogona kusimbiswa nemigumisiro yekuedza inotevera: kuwedzera kweMel secretion usiku kwakashata kwakabatana nekuderera kwehutano hwemwoyo;Melatonin mupineal gland inogona kudzivirira cardiac arrhythmia inokonzerwa ne-ischemia-reperfusion kukuvara, kukanganisa kudzora kweropa, kugadzirisa cerebral kuyerera kweropa, uye kugadzirisa mhinduro yeperipheral arteries kune norepinephrine.Naizvozvo, Mel anogona kudzora hurongwa hwemoyo.
Mukuwedzera, melatonin inodzorawo kufema system, digestive system uye urinary system.
Nguva yekutumira: Jun-22-2021