1,3-Dihydroxyacetone Nzira dzekugadzira uye maApplication sumo CAS 96-26-4

1,3-Dihydroxyacetone Nhanganyaya

1,3-Dihydroxyacetone is an organic compound ine molecular formula C3H6O3, iyo inonzi polyhydroxyketose uye ketose iri nyore.Chitarisiko ikristaro chena yehupfu, inonyungudika zviri nyore muorganic solvents senge mvura, ethanol, ether, uye acetone.Nzvimbo yakanyungudika i75-80 ℃, uye kunyungudika kwemvura kuri> 250g/L (20 ℃).Iine kuravira kunotapira uye yakagadzikana pa pH 6.0.1,3-Dihydroxyacetone inoderedza shuga.Ese mamonosaccharides (chero bedzi paine mahara aldehyde kana ketone carbonyl mapoka) ane reducibility.Dihydroxyacetone inosangana nemamiriro ari pamusoro, saka ndeye chikamu chekudzikisa shuga.

Kune kunyanya makemikari synthesis nzira uye microbial fermentation nzira.Pane nzira nhatu huru dzemakemikari dze1,3-dihydroxyacetone: electrocatalysis, metal catalytic oxidation, uye formaldehyde condensation.Iko kugadzirwa kwemakemikari ye1,3-dihydroxyacetone ichiri murabhoritari yekutsvaga nhanho.Kugadzirwa kwe1,3-dihydroxyacetone nenzira yebiological kune zvakakosha: yakakwira chigadzirwa, yakakwira glycerol shanduko uye mutengo wakaderera wekugadzira.Kugadzirwa kwe1,3-dihydroxyacetone muChina nekune dzimwe nyika kunonyanya kutora nzira ye microbial shanduko yeglycerol.

Chemcial synthesis nzira

1. 1,3-dihydroxyacetone inogadzirwa kubva ku1,3-dichloroacetone uye ethylene glycol sechinhu chikuru chekushandisa kuburikidza nekudzivirira carbonyl, etherification, hydrogenolysis, uye hydrolysis.1,3-dichloroacetone uye ethylene glycol zvinopisa uye zvinogadziriswa mu toluene kuti ibudise 2,2-dichloromethyl-1,3-dioxolane.Vanobva vaita ne sodium benzylidene muN, N-dimethylformamide kugadzira 2,2-dibenzyloxy-1,3-dioxolane, iyo inobva yave hydrogenated pasi pePd/C catalysis kuti igadzire 1,3-dioxolane-2,2-dimethanol, iyo. inobva yaiswa hydrolyzed muhydrochloric acid kugadzira 1,3-dihydroxyacetone.Iyo mbishi yekugadzira 1,3-dihydroxyacetone uchishandisa nzira iyi iri nyore kuwana, maitiro ekuita akapfava, uye Pd/C catalyst inogona kudzokororwa, iyo ine kukosha kwakakosha kwekushandisa.

2. 1,3-dihydroxyacetone yakagadzirwa kubva ku1,3-dichloroacetone uye methanol kuburikidza nekudzivirira carbonyl, etherification, hydrolysis, uye hydrolysis reactions.1,3-dichloroacetone inopindirana nemethanol yakawandisa anhydrous pamberi peinomwisa kugadzira 2,2-dimethoxy-1,3-dichloropropane, iyo inobva yapiswa ne sodium benzylate muN, N-dimethylformamide kugadzira 2,2-dimethoxy. -1,3-dibenzyloxypropane.Zvadaro hydrogenated pasi Pd/C catalysis kuburitsa 2,2-dimethoxy-1,3-propanediol, iyo inobva hydrolyzed mu hydrochloric asidhi kuburitsa 1,3-dihydroxyacetone.Iyi nzira inotsiva carbonyl mudziviriri kubva ethylene glycol kune methanol, zvichiita kuti zvive nyore kuparadzanisa uye kuchenesa chigadzirwa 1,3-dihydroxyacetone, iyo ine budiriro yakakosha uye kukosha kwekushandisa.

3. Synthesis ye1,3-dihydroxyacetone uchishandisa acetone, methanol, chlorine kana bromine sechinhu chikuru chekushandisa.Acetone, anhydrous methanol, uye chlorine gasi kana bromine inoshandiswa kugadzira 2,2-dimethoxy-1,3-dichloropropane kana 1,3-dibromo-2,2-dimethoxypropane kuburikidza nepoto imwe chete.Vanobva vaiswa etherified ne sodium benzylate kuti ibudise 2,2-dimethoxy-1,3-dibenzyloxypropane, iyo inobva yaiswa hydrogenated uye hydrolyzed kuti ibudise 1,3-dihydroxyacetone.Iyi nzira ine mamiriro ekuita zvinyoro, uye kuita kwe "poto imwe" inodzivirira kushandisa inodhura uye inotsamwisa 1,3-dichloroacetone, zvichiita kuti ive inodhura uye yakakosha pakusimudzira.

Applications

1,3-Dihydroxyacetone iketose inongoitika yega, inodyiwa, uye isina chepfu kumuviri wemunhu uye nharaunda.Iyo yakawanda inoshanda yekuwedzera iyo inogona kushandiswa mune zvekuzora, mishonga, uye maindasitiri ezvekudya.

Inoshandiswa muindasitiri yezvizoro

1,3-Dihydroxyacetone inonyanya kushandiswa semushonga wezvizoro muzvizoro, kunyanya sechidzitiro chezuva chine maitiro akakosha, anogona kudzivirira kubuda kwakanyanyisa kwehunyoro hweganda, uye kuita basa mukunyorovesa, kudzivirira kwezuva, uye kuchengetedzwa kwemwaranzi yeUV.Pamusoro pezvo, mapoka eketone anoshanda muDHA anogona kuita nemaamino acids uye mapoka emaamino eganda keratin kuti aite brown polymer, zvichiita kuti ganda revanhu ribudise ruvara rwebrown.Naizvozvo, inogona zvakare kushandiswa seyekufananidzira kuvhenekwa kwezuva kuti uwane ganda rebrown kana brownish rinotaridzika zvakafanana nemhedzisiro yekuratidzwa kwenguva refu kuchiedza chezuva, zvichiita kuti ritaridzike.

Kuvandudza nyama yakaonda kubva muzana yenguruve

1,3-Dihydroxyacetone chigadzirwa chepakati chemetabolism yeshuga, ichiita basa rinokosha mukugadzirisa shuga metabolism, kuderedza mafuta emuviri wenguruve uye kuvandudza nyama yakaonda muzana.Vashandi vekuJapan vesainzi uye tekinoroji vakaratidza kuburikidza nekuyedza kuti kuwedzera imwe chiyero cheDHA uye musanganiswa wepyruvate (calcium munyu) mukudya kwenguruve (mune 3: 1 uremu reshiyo) inogona kuderedza mafuta emukati yenguruve nyama ne12% kusvika 15%, uye mafuta emukati wegumbo nyama uye yakarebesa musana tsandanyama inoderedzwawo nenzira yakafanana, nekuwedzera kweprotein yemukati.

Zvekudya zvinoshanda

Kuwedzera 1,3-dihydroxyacetone (kunyanya pamwe chete nepyruvate) inogona kuvandudza metabolic rate yemuviri uye fatty acid oxidation, inogona kunyatsopisa mafuta kuderedza mafuta emuviri uye kunonoka kuwedzera uremu (kurasikirwa kwehuremu), uye kuderedza chiitiko che zvirwere zvinoenderana.Inogonawo kuvandudza insulin senitivity uye kuderedza plasma cholesterol level inokonzerwa nepamusoro cholesterol kudya.Yenguva refu yekuwedzera inogona kuwedzera chiyero chekushandiswa kweshuga yeropa uye kuchengetedza tsandanyama glycogen, Kune vatambi, inogona kuvandudza aerobic endurance performance.

Zvimwe zvinoshandiswa

1,3-dihydroxyacetone inogona zvakare kushandiswa zvakananga seantiviral reagent.Semuenzaniso, muhuku embryo tsika, kushandiswa kweDHA kunogona kudzivirira zvakanyanya hutachiona hwehuku distemper virus, kuuraya 51% kusvika 100% yehutachiona.Muindasitiri yematehwe, DHA inogona kushandiswa sechinhu chinodzivirira kune zvigadzirwa zvematehwe.Pamusoro pezvo, zvinodzivirira zvinonyanya kuumbwa neDHA zvinogona kushandiswa kuchengetedza nekuchengetedza michero nemiriwo, zvigadzirwa zvemumvura, uye zvigadzirwa zvenyama.